Preparation from alkali salts of the 3.3&lt;1&gt;-diamino-4.4&lt;1&gt;-dioxyarsenobenzene and process of making same.



j is aspecification on rnn isra'rns PAilENT oFFIo PAUL Enamel-I, or rRANKroRT-oN-THE-MAIN, AND BAPTIST REUTER, or nocnsr- ON-TIiE-MAIN, GERMANY, ASSIGNORS 'ro FARBWERKE vomvr. MEIs'rnn LUCIUS at BRU'NING, 01F HocHsT-oN-rHn-MAIN, GERMANY, A CGRPORATION or GERMANY,

PREPARATION FROM ALKALI' snLTs or THE 3.SIQDIAMINO-LL.4=-D1QXYARSENQBENZENE a AND PROCESS or MAKING SAME.

No Drawing.

To all whom} itmay concern:

Be it known that we, PAUL EHRLIGH, M.

D.,. professor of medicine, and Barrisr REUTER, Ph. D., chem1st, citizens of the Empire of Germany, residing. at .Ffank- I fort-on-the-Main and Hdchst-on-thdMain, Germany, respectively, have 1nvented cer- 'tain new and useful Improvements .m a

Preparation from Alkali Salts of the 3.3

'Diaminosed Dioxyarsenobenzene and Process of Making Same, of which the following The" alkali salts of the arsenophenols and their derivatives, as, for'instance, of 3.8 diamino't.4 -dioxyarsenobenzene are of great value for therapeutic purposes, for in stance as a remedyf'for syphilis; however, When in an isolated condition, they are not stable and the products formed from'them by decomposition) are highly toxic. Now we have found that the mixtures of said alkali salts with reducing agents, such as hy- *peutic purposes.

drosulfites or sulfoxylat'es, are obtainable by mixing the solutions of said compounds with solvents, which precipitate both the said alkali salts and the reducing agents, and are comparatively much .mo-re stable and therefore of particular value for theradiam mode -d ioxy a rsen ohenzene, the new preparati -ns so obtained are yellow powders, scarcely soluble in alcoholbut readily soluble with alkaline reaction in water.

' From their solutions, when they are poured (pure sodium formaldehyde sul'toxylate) dissolved in 3 ccm. of water are then addd to the alkaline solution, whereupon the soution becomes turbid and fiakesgradually separate, which are however soluble in water. lVithout having regard to this separation,

\Vhen working with 35 of 3.3 -diamino-4AP-.

the liquid is introduced with stirring into a very cold mixture of 300 com. of alcohol and 240 com. of pure ether. The sodium.

salt of the 'arseno compound isthus precipitated in a well-subdivided mixture with sulfoxylate; it is filtered otl', washed 'with absolute ether and pressed out.- All these operations are performed as] much aspossible'with exclusion of air, for instance in an atmosphere of nitrogen. Finally the preparation thus obtained is dried in mono in presence of sulfuricacid' It then forms a light yellow powder, very readily soluble in water with alkaline reaction,- but scarcely soluble in alcohol. Y

Having now described our invention-what we claim is:

Specification of Letters Patent. Patented NOV, 11, 1 913, Application filed November 15, 1912. Serial No. 731,612.

1. As new products, mixtures of alkali.

salts of the 8.3 -diamino-4A -dioxyarsenobenzene with a reducing agent, being yellow powders, readily solub-lein waterwith alkaline reaction, scarcely soluble in' alcohol, their solutions separating diaminodioxyarsenobenzene onpouring them into diluted hydrocholoric acid and then adding sodium carbonate.

2..As anew product, a mixture of the sodium salt of 3.3l-diamin04A -dioxyarsenoloenzene with sodium formaldehyde sulfoxylate, being a yellow powder, readily soluble in .water with alkaline reaction, scarcely soluble in alcohol, its solution'sepa rating diamin'odioxyarsenobenzene on pour mg it into diluted hydrocholoric acid and then adding sodium carbonate.

3. The process of preparing.a mixture of alkali salts ofarsenophen'ols and-sulfoxylates. which. consists in precipitating the mixture from a solutionof said compounds.

4. The process of preparing a mixture of alkali salts of 3.3 -diamino-4. P-dioxyarsen0-' benzene and sodium formaldehyde sulfoxylate, which consists in precipitating the mix ture from a solution of said compounds.

In testimony whereof, we affixour'si'gnatures in presence of two witnesses.

' PAUL EHRLICH. j BAPTIST REUTER.

Witnesses JEAN GRUND, CARL GRUND. 

